Advantage® II flea treatment for cats and dogs

Fight the misery of biting fleas with Advantage® II, a leading brand in flea prevention for over 25 years. This easy-to-apply topical flea treatment starts killing fleas within 12 hours and lasts for 30 days, no prescription required.

How does Advantage® II work?

Breaks the flea life cycle

Advantage® II’s ingredients kill all flea life stages — fleas, flea eggs and flea larvae — to prevent re-infestation.

How to apply Advantage® II Apply Advantage® II directly to your pet’s skin.* It goes on in seconds — no hard-to-swallow pills. Kills through contact

Unlike oral flea treatments, Advantage® II kills fleas through contact so they don’t have to bite your pet to die.

30-day continuous protection

How long does Advantage® II take to work? It starts killing fleas within 12 hours and and keeps working all month long.

*See product label for complete directions for use.

Ready to protect your pet with vet-recommended
Advantage® II?

Advantage® II spot-on flea treatment for cats, dogs and ferrets, too

Close-up of a cat and the Advantage II Large Cat pack

Advantage® II for Cats

Close-up of a dog lying on a mat and the Advantage II Small Dog pack

Advantage® II for Dogs

Close-up of a ferret being held in human hands and the Advantage II Ferret pack

Advantage® II for Ferrets

Find Advantage® II for Ferrets at your favorite pet care retailer.

Arm yourself against parasites with the Advantage® Family

The Advantage® Family is dead serious about pet parasites. That’s why we offer a full line of products designed to take out fleas, ticks, mosquitoes and more on your pet and around your home. If you're ready to show these bloodsuckers who’s boss, it's time to join the Family.

Top questions about Advantage® II for cats and dogs

Does Advantage® II for dogs expire?

There is no expiration date required on the packaging by the EPA for Advantage® II for dogs. The product should be kept in its original packaging and stored as directed on the label.

Can I bathe my dog after applying Advantage® II?

Yes. Advantage® II is waterproof after 24 hours. However, we suggest bathing your dog before applying Advantage® II. Just make sure your dog is dry before application. If you choose to bathe your dog in between treatments, we recommend use of a general grooming shampoo for pets. Keep in mind that more frequent bathing may keep the product from working the full 30 days.

Can my dog go swimming after I apply Advantage® II?

Yes! Your dog is free to take a dip after Advantage® II has been on for 24 hours. However, more frequent swimming may keep the product from working the full 30 days.

Can I apply Advantage® II for dogs on my cats?

No, do not use Advantage® II for dogs on cats. Please follow label directions for the application of our flea products.

How does Advantage® II for dogs work?

Advantage® II for dogs combines two active ingredients:

* Imidacloprid attacks the flea's nervous system - paralyzing and ultimately killing it.

* Pyriproxyfen is an insect growth regulator (IGR) that kills flea eggs and larvae.

This combination plays a crucial role in treating and preventing infestations, because:

* In an existing infestation, you might only be aware of the adult fleas, which only represent around 5% of the full infestation and are found on the pet.

* Immature flea life stages which live in the pet's environment consist of around 95% of the infestation and can be almost invisible to the naked eye.

What is the difference between Advantage® II for dogs and oral flea products?

Advantage® II flea prevention is applied to your dog topically, spreading over the skin and hair. It kills fleas through contact, so fleas do not have to bite your dog to die. With oral flea medications, fleas have to bite your dog and ingest the medication before they are killed.

How often can you use Advantage® II for dogs?

Use Advantage® II for dogs monthly, year-round to help keep your pet protected from fleas. Follow label directions for application.

How long does Advantage® II for dogs last?

A single application of Advantage® II for dogs stops biting fleas for one month. However, if the dog has a severe infestation, retreatment within a month may be necessary. See product label for additional information.

How do I apply Advantage® II for dogs?

Applying Advantage® II for dogs flea control to your canine companion is easy and convenient. Before applying, check the weight range and minimum age on the package to choose the appropriate product for your dog.

How to apply Advantage® II for dogs:

1. Remove the tube from packaging and open it by putting the cap on the other end and twisting to break the seal.

2. Place the tip of the tube on the skin between your dog's shoulder blades and gently squeeze to expel the solution on their skin. The number of application spots depends on the size and weight of your dog.

3. Lift the tube away from their skin, while maintaining pressure on the tube to make sure the product has all been squeezed out.

For more detailed instructions, watch our application video.